Guanylyl cyclase-G modulates jejunal apoptosis and inflammation in mice with intestinal ischemia and reperfusion.

Membrane bound guanylyl cyclase-G (mGC-G), a novel form of GC mediates ischemia and reperfusion (IR)-induced renal injury. We investigated the roles of mGC-G in intestinal IR-induced jejunal damage, inflammation, and apoptosis.Male C57BL/6 wild-type (WT) and mGC-G gene knockout (KO) mice were treate...

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Bibliographic Details
Main Authors: Hui-Chen Lo, Ruey-Bing Yang, Chien-Hsing Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4081647?pdf=render