Identification of apolipoprotein B–reactive CDR3 motifs allows tracking of atherosclerosis-related memory CD4+T cells in multiple donors

Identification of apolipoprotein B–reactive CDR3 motifs allows tracking of atherosclerosis-related memory CD4+T cells in multiple donors

IntroductionAtherosclerosis is a major pathological condition that underlies many cardiovascular diseases (CVDs). Its etiology involves breach of tolerance to self, leading to clonal expansion of autoreactive apolipoprotein B (APOB)–reactive CD4+T cells that correlates with clinical CVD. The T-cell...

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Detalhes bibliográficos
Principais autores: Payel Roy, Sujit Silas Armstrong Suthahar, Jeffrey Makings, Klaus Ley
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2024-03-01
coleção:Frontiers in Immunology
Assuntos:
atherosclerosis
antigen-specific
TCR-sequencing
APOB-reactive
CDR3 motifs
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302031/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302031/full

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