Breast cancer PDxO cultures for drug discovery and functional precision oncology

Breast cancer PDxO cultures for drug discovery and functional precision oncology

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Summary: Patient-derived xenografts (PDXs) have clinical value but are time-, cost-, and labor-intensive and thus ill-suited for large-scale experiments. Here, we present a protocol to convert PDX tumors into PDxOs for long-term cultures amenable to moderate-throughput drug screens, including in-dep...

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Bibliographic Details
Main Authors: Sandra D. Scherer, Ling Zhao, Andrew J. Butterfield, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Katrin P. Guillen, Bryan E. Welm, Alana L. Welm
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:STAR Protocols
Subjects:
Cell Culture
Cell-based Assays
Cancer
Model Organisms
Organoids
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166723003696

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http://www.sciencedirect.com/science/article/pii/S2666166723003696

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