Advanced single-cell and spatial analysis with high-multiplex characterization of circulating tumor cells and tumor tissue in prostate cancer: Unveiling resistance mechanisms with the CoDuCo in situ assay

Advanced single-cell and spatial analysis with high-multiplex characterization of circulating tumor cells and tumor tissue in prostate cancer: Unveiling resistance mechanisms with the CoDuCo in situ assay

Abstract Background Metastatic prostate cancer is a highly heterogeneous and dynamic disease and practicable tools for patient stratification and resistance monitoring are urgently needed. Liquid biopsy analysis of circulating tumor cells (CTCs) and circulating tumor DNA are promising, however, comp...

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Bibliographic Details
Main Authors: Lilli Bonstingl, Margret Zinnegger, Katja Sallinger, Karin Pankratz, Christin-Therese Müller, Elisabeth Pritz, Corinna Odar, Christina Skofler, Christine Ulz, Lisa Oberauner-Wappis, Anatol Borrás-Cherrier, Višnja Somođi, Ellen Heitzer, Thomas Kroneis, Thomas Bauernhofer, Amin El-Heliebi
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biomarker Research
Subjects:
Circulating tumor cells (CTCs)
Metastatic prostate cancer
Multiplex padlock probe in situ hybridization
Single-cell gene expression
Liquid biopsy
Spatial transcriptomics
Online Access:https://doi.org/10.1186/s40364-024-00680-z

Internet

https://doi.org/10.1186/s40364-024-00680-z

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