Homologous Prime-Boost Vaccination with OVA Entrapped in Self-Adjuvanting Archaeosomes Induces High Numbers of OVA-Specific CD8+ T Cells that Protect Against Subcutaneous B16-OVA Melanoma

Homologous Prime-Boost Vaccination with OVA Entrapped in Self-Adjuvanting Archaeosomes Induces High Numbers of OVA-Specific CD8+ T Cells that Protect Against Subcutaneous B16-OVA Melanoma

Homologous prime-boost vaccinations with live vectors typically fail to induce repeated strong CD8+ T cell responses due to the induction of anti-vector immunity, highlighting the need for alternative delivery vehicles. The unique ether lipids of archaea may be constituted into liposomes, archaeosom...

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Bibliographic Details
Main Authors: Felicity C. Stark, Michael J. McCluskie, Lakshmi Krishnan
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Vaccines
Subjects:
CD8 T cell response
archaeosome
prime-boost
B16
liposome
tumor vaccine
central memory
effector memory
Online Access:http://www.mdpi.com/2076-393X/4/4/44

Internet

http://www.mdpi.com/2076-393X/4/4/44

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