Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression

Ferroptosis has emerged to be a promising approach in cancer therapies; however, colorectal cancer (CRC) is relatively insensitive to ferroptosis. Exactly how the gut microenvironment impacts the ferroptotic sensitivity of CRC remains unknown. Herein, by performing metabolomics, we discovered that b...

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Bibliographic Details
Main Authors: Ying He, Yuhang Ling, Zhiyong Zhang, Randall Tyler Mertens, Qian Cao, Xutao Xu, Ke Guo, Qian Shi, Xilin Zhang, Lixia Huo, Kan Wang, Huihui Guo, Weiyun Shen, Manlu Shen, Wenming Feng, Peng Xiao
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Redox Biology
Subjects:
Colorectal cancer
Butyrate
Ferroptosis
xCT
c-Fos
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002239

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http://www.sciencedirect.com/science/article/pii/S2213231723002239

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