Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors

Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors

A series of hydrazine-1-carbothioamides derivatives (<b>3a</b>–<b>3j</b>) were synthesized and analyzed for inhibitory potential towards bovine carbonic anhydrase II (<i>b</i>-CA II) and 15-lipoxygenase (15-LOX). Interestingly, four derivatives, <b>3b</b&...

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Bibliographic Details
Main Authors: Pervaiz Ali Channar, Rima D. Alharthy, Syeda Abida Ejaz, Aamer Saeed, Jamshed Iqbal
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
carbonic anhydrase II
15-lipoxygenase
docking studies
thiourea
simulation
Online Access:https://www.mdpi.com/1420-3049/27/24/8723

Internet

https://www.mdpi.com/1420-3049/27/24/8723

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