Combining Hydrophilic Interaction Chromatography (HILIC) and Isotope Tagging for Off-Line LC-NMR Applications in Metabolite Analysis

Combining Hydrophilic Interaction Chromatography (HILIC) and Isotope Tagging for Off-Line LC-NMR Applications in Metabolite Analysis

The complementary use of liquid chromatography (LC) and nuclear magnetic resonance (NMR) has shown high utility in a variety of fields. While the significant benefit of spectral simplification can be achieved for the analysis of complex samples, other limitations remain. For example, 1H LC-NMR suffe...

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Bibliographic Details
Main Authors: Daniel Raftery, Tao Ye, Emmanuel Appiah-Amponsah, Kwadwo Owusu-Sarfo, G.A. Nagana Gowda
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Metabolites
Subjects:
metabolite profiling
metabolomics
NMR
HILIC
urine
15N isotope tagging
Online Access:http://www.mdpi.com/2218-1989/3/3/575

Internet

http://www.mdpi.com/2218-1989/3/3/575

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