Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection

Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection

IntroductionData from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.MethodsTo address whether Chi3l1 also contributes to TH2 responses following nematode infection, we infected Chi3l1...

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Bibliographic Details
Main Authors: Miranda L. Curtiss, Alexander F. Rosenberg, Christopher D. Scharer, Betty Mousseau, Natalia A. Ballesteros Benavides, John E. Bradley, Beatriz León, Chad Steele, Troy D. Randall, Frances E. Lund
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
IgE (immunoglobulin E)
helminth
germinal center
T follicular helper (T cell FH
T helper 2 (Th2) cells
enteric
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158493/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158493/full

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