Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies

Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies

Abstract Tumor‐associated macrophages (TAMs) promote the immune suppressive microenvironment inside tumors and are, therefore, considered as a promising target for the next generation of cancer immunotherapies. To repolarize their phenotype into a tumoricidal state, the Toll‐like receptor 7/8 agonis...

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Bibliographic Details
Main Authors: Evangelia Bolli, Maximilian Scherger, Sana M. Arnouk, Ana Rita Pombo Antunes, David Straßburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Räder, Sophie Hernot, Pol Besenius, Jo A. Van Ginderachter, Lutz Nuhn
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Advanced Science
Subjects:
cancer immunotherapy
drug delivery
M2 macrophages
nanobodies
repolarization
TLR 7/8 agonist
Online Access:https://doi.org/10.1002/advs.202004574

Internet

https://doi.org/10.1002/advs.202004574

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