Tumor microenvironment complexity and therapeutic implications at a glance
Abstract The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance end...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12964-020-0530-4 |
| _version_ | 1819162141884678144 |
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| author | Roghayyeh Baghban Leila Roshangar Rana Jahanban-Esfahlan Khaled Seidi Abbas Ebrahimi-Kalan Mehdi Jaymand Saeed Kolahian Tahereh Javaheri Peyman Zare |
| author_facet | Roghayyeh Baghban Leila Roshangar Rana Jahanban-Esfahlan Khaled Seidi Abbas Ebrahimi-Kalan Mehdi Jaymand Saeed Kolahian Tahereh Javaheri Peyman Zare |
| author_sort | Roghayyeh Baghban |
| collection | DOAJ |
| description | Abstract The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance ending in cancer cell progression and metastasis. The reciprocal cell-cell/ECM interaction and tumor cell hijacking of non-malignant cells force stromal cells to lose their function and acquire new phenotypes that promote development and invasion of tumor cells. Understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to indirectly disrupt cancer cell interplay and contribute to the development of efficient and safe therapeutic strategies to fight cancer. Furthermore, the tumor-derived circulating materials can also be used as cancer diagnostic tools to precisely predict and monitor the outcome of therapy. This review evaluates such potentials in various advanced cancer models, with a focus on 3D systems as well as lab-on-chip devices. Video abstract |
| first_indexed | 2024-12-22T17:23:32Z |
| format | Article |
| id | doaj.art-cad36407a50b47f8b471b605d11643a7 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-22T17:23:32Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-cad36407a50b47f8b471b605d11643a72022-12-21T18:18:46ZengBMCCell Communication and Signaling1478-811X2020-04-0118111910.1186/s12964-020-0530-4Tumor microenvironment complexity and therapeutic implications at a glanceRoghayyeh Baghban0Leila Roshangar1Rana Jahanban-Esfahlan2Khaled Seidi3Abbas Ebrahimi-Kalan4Mehdi Jaymand5Saeed Kolahian6Tahereh Javaheri7Peyman Zare8Drug Applied Research Center, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesDepartment of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical SciencesBiotechnology Research Center, Tabriz University of Medical SciencesDepartment of Neurosciences and Cognitive, School of Advanced Medical Sciences, Tabriz University of Medical SciencesNano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical SciencesDepartment of Experimental and Clinical Pharmacology and Pharmacogenomics, University Hospital TuebingenHealth Informatics Lab, Metropolitan College, Boston UniversityDioscuri Center of Chromatin Biology and Epigenomics, Nencki Institute of Experimental Biology, Polish Academy of SciencesAbstract The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance ending in cancer cell progression and metastasis. The reciprocal cell-cell/ECM interaction and tumor cell hijacking of non-malignant cells force stromal cells to lose their function and acquire new phenotypes that promote development and invasion of tumor cells. Understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to indirectly disrupt cancer cell interplay and contribute to the development of efficient and safe therapeutic strategies to fight cancer. Furthermore, the tumor-derived circulating materials can also be used as cancer diagnostic tools to precisely predict and monitor the outcome of therapy. This review evaluates such potentials in various advanced cancer models, with a focus on 3D systems as well as lab-on-chip devices. Video abstracthttp://link.springer.com/article/10.1186/s12964-020-0530-4Cancer cell interactionsTumor microenvironmentExtracellular matrixCancer therapyStroma cellCirculating tumor cells |
| spellingShingle | Roghayyeh Baghban Leila Roshangar Rana Jahanban-Esfahlan Khaled Seidi Abbas Ebrahimi-Kalan Mehdi Jaymand Saeed Kolahian Tahereh Javaheri Peyman Zare Tumor microenvironment complexity and therapeutic implications at a glance Cell Communication and Signaling Cancer cell interactions Tumor microenvironment Extracellular matrix Cancer therapy Stroma cell Circulating tumor cells |
| title | Tumor microenvironment complexity and therapeutic implications at a glance |
| title_full | Tumor microenvironment complexity and therapeutic implications at a glance |
| title_fullStr | Tumor microenvironment complexity and therapeutic implications at a glance |
| title_full_unstemmed | Tumor microenvironment complexity and therapeutic implications at a glance |
| title_short | Tumor microenvironment complexity and therapeutic implications at a glance |
| title_sort | tumor microenvironment complexity and therapeutic implications at a glance |
| topic | Cancer cell interactions Tumor microenvironment Extracellular matrix Cancer therapy Stroma cell Circulating tumor cells |
| url | http://link.springer.com/article/10.1186/s12964-020-0530-4 |
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