Implication of the cooking oil-peroxidation product “hydroxynonenal” for Alzheimer’s disease

Implication of the cooking oil-peroxidation product “hydroxynonenal” for Alzheimer’s disease

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that reduces cell injuries via detoxification of lipid-peroxidation product, 4-hydroxy-2-nonenal (hydroxynonenal). It is generated exogenously via deep-frying of linoleic acid-rich cooking oils and/or endogenously via oxidation of fatty acid...

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Bibliographic Details
Main Authors: Tetsumori Yamashima, Takuya Seike, Daria Mochly-Rosen, Che-Hong Chen, Mitsuru Kikuchi, Eishiro Mizukoshi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyloid β
calpain–cathepsin hypothesis
Hsp70.1
lysosome
neuronal death
PUFA
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1211141/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1211141/full

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