Pyrrolyldihydropyrazino[1,2-a]indoletrione Analogue Microtubule Inhibitor Induces Cell-Cycle Arrest and Apoptosis in Colorectal Cancer Cells

Pyrrolyldihydropyrazino[1,2-a]indoletrione Analogue Microtubule Inhibitor Induces Cell-Cycle Arrest and Apoptosis in Colorectal Cancer Cells

In this study, 2-benzyl-10a-(1<i>H</i>-pyrrol-2-yl)-2,3-dihydropyrazino[1,2-<i>a</i>]indole-1,4,10(10a<i>H</i>)-trione (DHPITO), a previously identified inhibitor against hepatocellular carcinoma cells, is shown to exert its cytotoxic effects by suppressing the pr...

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Bibliographic Details
Main Authors: Dong-Lin Yang, Hong-Xia Qin, Na-Na Zhang, Ya-Jun Zhang, Jiu-Hong Huang, Chun-Sheng Hu, Xiao-Xue Zhang, Yong Li, Liu-Jun He
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
DHPITO
colorectal cancer cells
tubulin
G2/M phase
apoptosis
cell migration
Online Access:https://www.mdpi.com/1420-3049/28/4/1948

Internet

https://www.mdpi.com/1420-3049/28/4/1948

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