Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy

Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy

The metabolic dependencies of cancer cells have substantial potential to be exploited to improve the diagnosis and treatment of cancer. Creatine riboside (CR) is identified as a urinary metabolite associated with risk and prognosis in lung and liver cancer. However, the source of high CR levels in p...

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Bibliographic Details
Main Authors: Amelia L. Parker, Leila Toulabi, Takahiro Oike, Yasuyuki Kanke, Daxeshkumar Patel, Takeshi Tada, Sheryse Taylor, Jessica A. Beck, Elise Bowman, Michelle L. Reyzer, Donna Butcher, Skyler Kuhn, Gary T. Pauly, Kristopher W. Krausz, Frank J. Gonzalez, S. Perwez Hussain, Stefan Ambs, Bríd M. Ryan, Xin Wei Wang, Curtis C. Harris
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-07-01
Series:The Journal of Clinical Investigation
Subjects:
Oncology
Online Access:https://doi.org/10.1172/JCI157410

Internet

https://doi.org/10.1172/JCI157410

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