Prediction of long-term polysorbate degradation according to short-term degradation kinetics

Prediction of long-term polysorbate degradation according to short-term degradation kinetics

ABSTRACTPolysorbates (PSs) are a class of surfactants commonly used in the formulation of protein therapeutic agents to provide protection against denaturation and aggregation. When the PS in these drug formulations degrades, loss of stabilization of the protein therapeutic and formulation may occur...

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Bibliographic Details
Main Authors: Sisi Zhang, Caterina Riccardi, Dane Carlson, Douglas Kamen, Kenneth S. Graham, Mohammed Shameem, Hanne Bak, Hui Xiao, Ning Li
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Free fatty acids
lipase activity
long-term stability
polysorbate hydrolysis
short-term kinetics
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2232486

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https://www.tandfonline.com/doi/10.1080/19420862.2023.2232486

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