Prediction of long-term polysorbate degradation according to short-term degradation kinetics
ABSTRACTPolysorbates (PSs) are a class of surfactants commonly used in the formulation of protein therapeutic agents to provide protection against denaturation and aggregation. When the PS in these drug formulations degrades, loss of stabilization of the protein therapeutic and formulation may occur...
Main Authors: | Sisi Zhang, Caterina Riccardi, Dane Carlson, Douglas Kamen, Kenneth S. Graham, Mohammed Shameem, Hanne Bak, Hui Xiao, Ning Li |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2023-12-01
|
Series: | mAbs |
Subjects: | |
Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2023.2232486 |
Similar Items
-
Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation
by: Benedykt Kozuch, et al.
Published: (2023-09-01) -
The effect of polysorbate 20 and polysorbate 80 on the solubility of quercetin
by: Tristiana Erawati, et al.
Published: (2023-03-01) -
Oxidation of polysorbates – An underestimated degradation pathway?
by: Johanna Weber, et al.
Published: (2023-12-01) -
Quantitation of polysorbate 80 in recombinant protein formulation using high-performance liquid chromatography
by: A. D. Askretkov, et al.
Published: (2022-04-01) -
Polysorbate 80 – Modulated nanocrystallization for enhancement of griseofulvin solubility
by: Emmanuel O. Olorunsola, et al.
Published: (2024-01-01)