WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC
WNT signaling enhances MYC expression in cancer cells to increase the rate of cell proliferation. We have recently found that this principle involves the gating of MYC to nuclear pores mediated by an oncogenic super-enhancer in a ß-catenin-dependent manner in colon cancer cells. This phenomenon, whi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-03-01
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| Series: | Molecular & Cellular Oncology |
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| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1710992 |