WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC
WNT signaling enhances MYC expression in cancer cells to increase the rate of cell proliferation. We have recently found that this principle involves the gating of MYC to nuclear pores mediated by an oncogenic super-enhancer in a ß-catenin-dependent manner in colon cancer cells. This phenomenon, whi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-03-01
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| Series: | Molecular & Cellular Oncology |
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| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1710992 |
| _version_ | 1797677171534200832 |
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| author | Anita Göndör |
| author_facet | Anita Göndör |
| author_sort | Anita Göndör |
| collection | DOAJ |
| description | WNT signaling enhances MYC expression in cancer cells to increase the rate of cell proliferation. We have recently found that this principle involves the gating of MYC to nuclear pores mediated by an oncogenic super-enhancer in a ß-catenin-dependent manner in colon cancer cells. This phenomenon, which is absent in normal cells, leads to pathological levels of MYC expression. |
| first_indexed | 2024-03-11T22:41:12Z |
| format | Article |
| id | doaj.art-cae325ceee654fba940bcf450580a704 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:12Z |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-cae325ceee654fba940bcf450580a7042023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-03-017210.1080/23723556.2019.17109921710992WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYCAnita Göndör0Karolinska University Hospital, BioclinicumWNT signaling enhances MYC expression in cancer cells to increase the rate of cell proliferation. We have recently found that this principle involves the gating of MYC to nuclear pores mediated by an oncogenic super-enhancer in a ß-catenin-dependent manner in colon cancer cells. This phenomenon, which is absent in normal cells, leads to pathological levels of MYC expression.http://dx.doi.org/10.1080/23723556.2019.1710992wnt signallingchromatinnuclear architecturenuclear poremyc super-enhancer |
| spellingShingle | Anita Göndör WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC Molecular & Cellular Oncology wnt signalling chromatin nuclear architecture nuclear pore myc super-enhancer |
| title | WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC |
| title_full | WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC |
| title_fullStr | WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC |
| title_full_unstemmed | WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC |
| title_short | WNT-mediated gene gating: a novel principle connecting oncogenic super-enhancers with the nuclear pore to drive pathological expression of MYC |
| title_sort | wnt mediated gene gating a novel principle connecting oncogenic super enhancers with the nuclear pore to drive pathological expression of myc |
| topic | wnt signalling chromatin nuclear architecture nuclear pore myc super-enhancer |
| url | http://dx.doi.org/10.1080/23723556.2019.1710992 |
| work_keys_str_mv | AT anitagondor wntmediatedgenegatinganovelprincipleconnectingoncogenicsuperenhancerswiththenuclearporetodrivepathologicalexpressionofmyc |