Substrate stiffness controls proinflammatory responses in human gingival fibroblasts

Abstract Soft gingiva is often compromised in gingival health; however, the underlying biological mechanisms remain unknown. Extracellular matrix (ECM) stiffness is involved in the progression of various fibroblast-related inflammatory disorders via cellular mechanotransduction. Gingival stiffness m...

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Bibliographic Details
Main Authors: Watcharaphol Tiskratok, Masahiro Yamada, Jun Watanabe, Nadia Kartikasari, Tsuyoshi Kimura, Hiroshi Egusa
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28541-z