Hemopexin and albumin inhibit heme-induced macrophage activation while also enabling heme-LPS synergistic promotion of TNF production

Hemopexin and albumin inhibit heme-induced macrophage activation while also enabling heme-LPS synergistic promotion of TNF production

Free heme released from hemoglobin contributes to exacerbated inflammation and tissue damage in hemolytic diseases. While a moderate level of free heme does not cause intravascular inflammation by itself, its presence during infection greatly enhances inflammation. Although specific serum proteins h...

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Bibliographic Details
Main Authors: Rafael Cardoso Maciel Costa Silva, Luis Batista Tan, Andreza Moreira dos Santos Gama, Nuccia Nicole Theodoro De Cicco, Nicolas S. Merle, Lubka T. Roumenina, Yi Zhang, Gregory C. Henderson, André N.A. Gonçalves, Georgia C. Atella, João Trindade Marques, Leonardo Holanda Travassos, Claudia N. Paiva, Bénédicte Manoury, Marcelo Torres Bozza
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Advances in Redox Research
Subjects:
Albumin
Hemopexin
Heme
Inflammation
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S2667137923000097

Internet

http://www.sciencedirect.com/science/article/pii/S2667137923000097

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