Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite

Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite

Tyrosine-decahydrofluorene derivatives feature a fused [6.5.6] tricarbocyclic core and a 13-membered para-cyclophane ether. Herein, we identified new xenoacremones A, B, and C (1−3) from the fungal strain Xenoacremonium sinensis ML-31 and elucidated their biosynthetic pathway using gene deletion in...

Full description

Bibliographic Details
Main Authors: Zhiguo Liu, Wei Li, Peng Zhang, Jie Fan, Fangbo Zhang, Caixia Wang, Shuming Li, Yi Sun, Shilin Chen, Wenbing Yin
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Tyrosine-decahydrofluorene
Biosynthesis
PKS−NRPS
Xenoacremone
Heterologous expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001064

Internet

http://www.sciencedirect.com/science/article/pii/S2211383521001064

Similar Items