Toxicological mechanism of triptolide-induced liver injury: Caspase3-GSDME-mediated pyroptosis of Kupffer cell

Toxicological mechanism of triptolide-induced liver injury: Caspase3-GSDME-mediated pyroptosis of Kupffer cell

Aim: Triptolide (TRI) is an active diterpenoid lactone compound isolated from Tripterygium wilfordii,We focused on investigating the effect and mechanism of Triptolide (TRI) on liver injury. Methods: The toxic dose (LD50 = 100 μM) of TRI on liver Kupffer cells was explored, and network pharmacologic...

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Bibliographic Details
Main Authors: Chenyang Han, Hongyan Pei, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Li Guo, Yun Kong, Yi Yang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Triptolide
Liver injury
Kupffer cell
Pyroptosis
Caspase-3
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323004670

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http://www.sciencedirect.com/science/article/pii/S0147651323004670

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