Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival

Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival

We recently reported that oxidized LDL (oxLDL) induces an oscillatory increase in intracellular calcium ([Ca2+]i) levels in macrophages. Furthermore, we have shown that these [Ca2+]i oscillations mediate oxLDL's ability to inhibit macrophage apoptosis in response to growth factor deprivation. H...

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Bibliographic Details
Main Authors: Johnny H. Chen, Maziar Riazy, Shih Wei Wang, Jiazhen Minnie Dai, Vincent Duronio, Urs P. Steinbrecher
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Journal of Lipid Research
Subjects:
sphingosine-1-phosphate
calcium
foam cells
plaque stability
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410545

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http://www.sciencedirect.com/science/article/pii/S0022227520410545

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