Severe central nervous system demyelination in Sanfilippo disease

Severe central nervous system demyelination in Sanfilippo disease

IntroductionChronic progressive neuroinflammation is a hallmark of neurological lysosomal storage diseases, including mucopolysaccharidosis III (MPS III or Sanfilippo disease). Since neuroinflammation is linked to white matter tract pathology, we analyzed axonal myelination and white matter density...

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Bibliographic Details
Main Authors: Mahsa Taherzadeh, Erjun Zhang, Irene Londono, Benjamin De Leener, Sophie Wang, Jonathan D. Cooper, Timothy E. Kennedy, Carlos R. Morales, Zesheng Chen, Gregory A. Lodygensky, Alexey V. Pshezhetsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mucopolysaccharidosis
oligodendrocyte
myelination
lysosomal storage
GM3 ganglioside
diffusion basis spectrum imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1323449/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1323449/full

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