Posttranslational modification of Aurora A‐NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma

Posttranslational modification of Aurora A‐NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma

Abstract Background t(4;14)(p16;q32) cytogenetic abnormality renders high level of histone methyltransferase NSD2 in multiple myeloma (MM) patients, and predicts poor clinical prognosis, but mechanisms of NSD2 in promoting chemoresistance have not been well elucidated. Methods An epigenetics compoun...

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Bibliographic Details
Main Authors: Hongmei Jiang, Yixuan Wang, Jingjing Wang, Yafei Wang, Sheng Wang, Enyang He, Jing Guo, Ying Xie, Jingya Wang, Xin Li, Ziyi Peng, Mengqi Wang, Jian Hou, Zhiqiang Liu
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Clinical and Translational Medicine
Subjects:
Aurora kinase A
multiple myeloma
NSD2
posttranslational modification
Online Access:https://doi.org/10.1002/ctm2.744

Internet

https://doi.org/10.1002/ctm2.744

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