Structure-based design and construction of a synthetic phage display nanobody library

Structure-based design and construction of a synthetic phage display nanobody library

Abstract Objective To design and construct a new synthetic nanobody library using a structure-based approach that seeks to maintain high protein stability and increase the number of functional variants within the combinatorial space of mutations. Results Synthetic nanobody (Nb) libraries are emergin...

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Bibliographic Details
Main Authors: Ernesto Moreno, Mario S. Valdés-Tresanco, Andrea Molina-Zapata, Oliberto Sánchez-Ramos
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Research Notes
Subjects:
Nanobody
Synthetic nanobody library
Phage display
Structure-based design
Online Access:https://doi.org/10.1186/s13104-022-06001-7

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