Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol

Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol

Introduction Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer’s disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and pose limitations in terms of cost and logistics. Arterial spin...

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Bibliographic Details
Main Authors: Catherine Morgan, Frederik Barkhof, David L Thomas, Saima Hilal, Moritz Brandt, Betty M Tijms, Majon Muller, Tormod Fladby, Jennifer Linn, Per Selnes, Atle Bjørnerud, Elsmarieke M van de Giessen, Beatriz Padrela, Amnah Mahroo, Mervin Tee, Markus H Sneve, Paulien Moyaert, Oliver Geier, Joost P A Kuijer, Soetkin Beun, Wibeke Nordhøy, Yufei David Zhu, Mareike A Buck, Daniel C Hoinkiss, Simon Konstandin, Jörn Huber, Julia Wiersinga, Roos Rikken, Diederick de Leeuw, Håkon Grydeland, Lynette Tippett, Erin E Cawston, Esin Ozturk-Isik, Anders Fjell, Kristine Walhovd, Lene Pålhaugen, Patricia Clement, Eric Achten, Udunna Anazodo, Klaus Eickel, Jan Petr, Matthias Günther, Henk J M M Mutsaerts
Format: Article
Language:English
Published: BMJ Publishing Group 2024-03-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/3/e081635.full

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https://bmjopen.bmj.com/content/14/3/e081635.full

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