Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA

The processing of DNA double-strand breaks (DSBs) depends on the dynamic characteristics of chromatin. To investigate how abrupt changes in chromatin compaction alter these dynamics and affect DSB processing and repair, we exposed irradiated cells to hypotonic stress (HypoS). Densitometric and chrom...

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Bibliographic Details
Main Authors: Lisa Marie Krieger, Emil Mladenov, Aashish Soni, Marilen Demond, Martin Stuschke, George Iliakis
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
DNA double-strand breaks
DNA-damage-response
chromatin
chromatin dynamics
hypotonic stress (HypoS)
homologous recombination (HR)
Online Access:https://www.mdpi.com/1422-0067/22/20/10957

Internet

https://www.mdpi.com/1422-0067/22/20/10957

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