Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions

Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions

New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerfu...

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Bibliographic Details
Main Authors: Angela Trejo, Carme Masdeu, Irene Serrano-Pérez, Marina Pedrola, Narcís Juanola, Ouldouz Ghashghaei, Guadalupe Jiménez-Galisteo, Rodolfo Lavilla, Francisco Palacios, Concepción Alonso, Miguel Viñas
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antibiotics
Subjects:
antibiotics
drugs
multicomponent reactions
mycobacteria
resistant bacteria
Online Access:https://www.mdpi.com/2079-6382/12/1/83

Internet

https://www.mdpi.com/2079-6382/12/1/83

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