Identification of compounds with activity against Trypanosoma cruzi within a collection of synthetic nucleoside analogs

Identification of compounds with activity against Trypanosoma cruzi within a collection of synthetic nucleoside analogs

IntroductionChagas disease is caused by the protozoan parasite Trypanosoma cruzi, and it is the most important neglected tropical disease in the Americas. Two drugs are available to treat the infection, but their efficacy in the chronic stage of the disease, when most cases are diagnosed, is reduced...

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Main Authors: Berta Barnadas-Carceller, Nieves Martinez-Peinado, Laura Córdoba Gómez, Albert Ros-Lucas, Juan Carlos Gabaldón-Figueira, Juan J. Diaz-Mochon, Joaquim Gascon, Ignacio J. Molina, María José Pineda de las Infantas y Villatoro, Julio Alonso-Padilla
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chagas disease
Trypanosoma cruzi
purine derivates
antiparasitic assays
cytotoxicity assays
drug discovery cascade
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1067461/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.1067461/full

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