Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT

Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT

Ayala Mariscal et al have identified and characterized the interface of pathogenic Huntingtin and the molecular chaperone DNAJB1. Histidine-244 of the C-terminal domain of DNAJB1 is a key residues for binding to the poly-proline region of HTT. This binding site is specific for the interaction with H...

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Bibliographische Detailangaben
Hauptverfasser: S. M. Ayala Mariscal, M. L. Pigazzini, Y. Richter, M. Özel, I. L. Grothaus, J. Protze, K. Ziege, M. Kulke, M. ElBediwi, J. V. Vermaas, L. Colombi Ciacchi, S. Köppen, F. Liu, J. Kirstein
Format: Artikel
Sprache:English
Veröffentlicht: Nature Portfolio 2022-08-01
Schriftenreihe:Nature Communications
Online Zugang:https://doi.org/10.1038/s41467-022-32370-5

Online

https://doi.org/10.1038/s41467-022-32370-5

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