Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
For reactions producing numerous chiral centres, accessing all potential stereoisomers is synthetically appealing but difficult. Here, the authors report a stereodivergent 1,6-addition of azlactones where minimal changes to the catalyst structure switches the product selectivity.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14793 |