Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism
SIRT1, an NAD+-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metaboli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/16/1/950 |
| _version_ | 1811201210318848000 |
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| author | Glenn E. Simmons Wendy M. Pruitt Kevin Pruitt |
| author_facet | Glenn E. Simmons Wendy M. Pruitt Kevin Pruitt |
| author_sort | Glenn E. Simmons |
| collection | DOAJ |
| description | SIRT1, an NAD+-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metabolic programs in response to diverse physiological stress. Interestingly, many of the metabolic pathways that are influenced by SIRT1 are also altered in tumor development. Not only does SIRT1 have the potential to regulate oncogenic factors, it also orchestrates many aspects of metabolism and lipid regulation and recent reports are beginning to connect these areas. SIRT1 influences pathways that provide an alternative means of deriving energy (such as fatty acid oxidation and gluconeogenesis) when a cell encounters nutritive stress, and can therefore lead to altered lipid metabolism in various pathophysiological contexts. This review helps to show the various connections between SIRT1 and major pathways in cellular metabolism and the consequence of SIRT1 deregulation on carcinogenesis and lipid metabolism. |
| first_indexed | 2024-04-12T02:17:07Z |
| format | Article |
| id | doaj.art-cb14899e585a4292b5439f3175d88828 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T02:17:07Z |
| publishDate | 2015-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cb14899e585a4292b5439f3175d888282022-12-22T03:52:13ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-01-0116195096510.3390/ijms16010950ijms16010950Diverse Roles of SIRT1 in Cancer Biology and Lipid MetabolismGlenn E. Simmons0Wendy M. Pruitt1Kevin Pruitt2Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 6591, Lubbock, TX 79430-6591, USADepartment of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 6591, Lubbock, TX 79430-6591, USASIRT1, an NAD+-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metabolic programs in response to diverse physiological stress. Interestingly, many of the metabolic pathways that are influenced by SIRT1 are also altered in tumor development. Not only does SIRT1 have the potential to regulate oncogenic factors, it also orchestrates many aspects of metabolism and lipid regulation and recent reports are beginning to connect these areas. SIRT1 influences pathways that provide an alternative means of deriving energy (such as fatty acid oxidation and gluconeogenesis) when a cell encounters nutritive stress, and can therefore lead to altered lipid metabolism in various pathophysiological contexts. This review helps to show the various connections between SIRT1 and major pathways in cellular metabolism and the consequence of SIRT1 deregulation on carcinogenesis and lipid metabolism.http://www.mdpi.com/1422-0067/16/1/950sirtuinSIRT1metabolismcancerlipolysislipidssteatosisfatty acidsterol regulatory element-binding protein (SREBP) |
| spellingShingle | Glenn E. Simmons Wendy M. Pruitt Kevin Pruitt Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism International Journal of Molecular Sciences sirtuin SIRT1 metabolism cancer lipolysis lipids steatosis fatty acid sterol regulatory element-binding protein (SREBP) |
| title | Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism |
| title_full | Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism |
| title_fullStr | Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism |
| title_full_unstemmed | Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism |
| title_short | Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism |
| title_sort | diverse roles of sirt1 in cancer biology and lipid metabolism |
| topic | sirtuin SIRT1 metabolism cancer lipolysis lipids steatosis fatty acid sterol regulatory element-binding protein (SREBP) |
| url | http://www.mdpi.com/1422-0067/16/1/950 |
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