Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

Abstract Background Cathepsin S (CTSS) is a cysteine protease that played diverse roles in immunity, tumor metastasis, aging and other pathological alterations. At the cellular level, increased CTSS levels have been associated with the secretion of pro-inflammatory cytokines and disrupted the homeos...

Full description

Bibliographic Details
Main Authors: Hao-Wei Lee, Szu-Jung Chen, Kuen-Jer Tsai, Kuei-Sen Hsu, Yi-Fan Chen, Chih-Hua Chang, Hsiao-Han Lin, Wen-Yun Hsueh, Hsing-Pang Hsieh, Yueh-Feng Lee, Huai-Chueh Chiang, Jang-Yang Chang
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Biomedical Science
Subjects:
Cathepsin S
Cognitive function
OLF-1
Brain-derived neurotrophic factor
Online Access:https://doi.org/10.1186/s12929-024-01037-2

Internet

https://doi.org/10.1186/s12929-024-01037-2

Similar Items