Prospective Observational Study of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma: Microbiota Profiling and Cytokine Expression

Prospective Observational Study of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma: Microbiota Profiling and Cytokine Expression

PurposeDefine incidence and risk factors of osteonecrosis of the jaw (ONJ) and explore oral microbial signatures and host immune response as reflected by cytokine changes in saliva and serum in multiple myeloma (MM) patients on bisphosphate (BP) therapy.Patients and MethodsA single center observatio...

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Bibliographic Details
Main Authors: Ashraf Z. Badros, Mariam Meddeb, Dianna Weikel, Sunita Philip, Todd Milliron, Rena Lapidus, Lisa Hester, Olga Goloubeva, Timothy F. Meiller, Emmanuel F. Mongodin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
osteonecrosis of the jaw
bisphosphanates
microbiome
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.704722/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.704722/full

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