Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype

Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype

Tumor-associated macrophages (TAMs) are an abundant tumor-promoting cell type in the tumor microenvironment (TME). Most TAMs exhibit a pro-tumor M2-like phenotype supportive of tumor growth, immune evasion, and metastasis. IL-4 and IL-13 are major cytokines that polarize macrophages to an M2 subset...

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Bibliographic Details
Main Authors: Amber E. de Groot, Kayla V. Myers, Timothy E.G. Krueger, W. Nathaniel Brennen, Sarah R. Amend, Kenneth J. Pienta
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Prostate cancer
Macrophage
IL-4R alpha
IL-4
Dupilumab
Dupixent
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000574

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http://www.sciencedirect.com/science/article/pii/S1476558622000574

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