Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathyResearch in context

Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathyResearch in context

Summary: Background: SARS-CoV-2 infection is considered as a relapsing inflammatory process with a dysregulation of IL-6 signalling. Classic IL-6 signalling is thought to represent a defence mechanism against pathogens. In contrast, IL-6 trans-signalling has pro-inflammatory effects. In severe COVI...

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Bibliographic Details
Main Authors: María Ángeles Rodríguez-Hernández, Mercedes Baena-Bustos, David Carneros, Carola Zurita-Palomo, Pablo Muñoz-Pinillos, Jaime Millán, Francisco Javier Padillo, Cristian Smerdou, Cayetano von Kobbe, Stefan Rose-John, Matilde Bustos
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:EBioMedicine
Subjects:
IL-6 trans-signalling
sgp130Fc
SARS-CoV-2
K18-hACE2 transgenic mice
COVID-19
Endotheliopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424001671

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http://www.sciencedirect.com/science/article/pii/S2352396424001671

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