Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation

Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation

We have previously shown that Zinc supplementation triggered ER stress/UPR in cancer cells undergoing treatment by genotoxic agents, reactivated wtp53 in cancer cells harboring mutant p53 (mutp53) and potentiated the activity of wtp53 in those carrying wtp53. In this study, we used Zinc chloride alo...

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Bibliographic Details
Main Authors: Roberta Gonnella, Luisa Guttieri, Maria Saveria Gilardini Montani, Roberta Santarelli, Erica Bassetti, Gabriella D’Orazi, Mara Cirone
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biology
Subjects:
ER stress/UPR
DDR
CHOP
ERK1/2
p53
PEL
Online Access:https://www.mdpi.com/2079-7737/11/1/132

Internet

https://www.mdpi.com/2079-7737/11/1/132

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