Challenges in describing the conformation and dynamics of proteins with ambiguous behavior

Challenges in describing the conformation and dynamics of proteins with ambiguous behavior

Traditionally, our understanding of how proteins operate and how evolution shapes them is based on two main data sources: the overall protein fold and the protein amino acid sequence. However, a significant part of the proteome shows highly dynamic and/or structurally ambiguous behavior, which canno...

Full description

Bibliographic Details
Main Authors: Joel Roca-Martinez, Tamas Lazar, Jose Gavalda-Garcia, David Bickel, Rita Pancsa, Bhawna Dixit, Konstantina Tzavella, Pathmanaban Ramasamy, Maite Sanchez-Fornaris, Isel Grau, Wim F. Vranken
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein dynamics and conformation
sequence-based prediction
biophysical characteristics
post-translational modification (PTM)
deleterious mutation
folding-upon-binding
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.959956/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.959956/full

Similar Items