Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption

To identify novel inhibitors of Mycobacterium tuberculosis cell envelope biosynthesis, we employed a two-step approach. First, we screened the diverse synthetic small molecule 71,544-compound Enamine library for growth inhibitors using the non-pathogenic surrogate Mycobacterium bovis BCG as screenin...

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Bibliographic Details
Main Authors: Annanya Shetty, Zhujun Xu, Umayal Lakshmanan, Jeffrey Hill, Meng Ling Choong, Shu-Sin Chng, Yoshiyuki Yamada, Anders Poulsen, Thomas Dick, Martin Gengenbacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
iniBAC
cell envelope stress
flippase
high throughput screen
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02960/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02960/full

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