No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris
Plasma concentrations of trimethylamine N-oxide (TMAO) have been linked to cardiovascular disease (CVD) risk and mortality. TMAO is formed through the bacterial conversion of trimethylamine which is obtained either directly from food, generated from dietary precursors (e.g. choline) or derived from...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Human Nutrition & Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149720300025 |
| _version_ | 1819000406241443840 |
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| author | Anthea Van Parys Vegard Lysne Jannike Øyen Jutta Dierkes Ottar Nygård |
| author_facet | Anthea Van Parys Vegard Lysne Jannike Øyen Jutta Dierkes Ottar Nygård |
| author_sort | Anthea Van Parys |
| collection | DOAJ |
| description | Plasma concentrations of trimethylamine N-oxide (TMAO) have been linked to cardiovascular disease (CVD) risk and mortality. TMAO is formed through the bacterial conversion of trimethylamine which is obtained either directly from food, generated from dietary precursors (e.g. choline) or derived from endogenous trimethyllysine (TML) production. In a previous article, we reported an increased risk of acute myocardial infarction with increased total choline intake in patients with stable angina pectoris. Due to the close link between TMAO, TML, choline metabolism and possibly CVD, we investigated whether plasma TMAO and TML modified the effect of total choline intake on acute myocardial infarction (AMI) risk in a post-hoc analysis. We found plasma TMAO and TML do not modify the association between higher dietary choline intake and increased AMI risk. Additionally, this association is not mediated via TMAO. |
| first_indexed | 2024-12-20T22:32:48Z |
| format | Article |
| id | doaj.art-cb2907f7f0e44a5c8533621fb8541a19 |
| institution | Directory Open Access Journal |
| issn | 2666-1497 |
| language | English |
| last_indexed | 2024-12-20T22:32:48Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj.art-cb2907f7f0e44a5c8533621fb8541a192022-12-21T19:24:41ZengElsevierHuman Nutrition & Metabolism2666-14972020-09-0121200112No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectorisAnthea Van Parys0Vegard Lysne1Jannike Øyen2Jutta Dierkes3Ottar Nygård4Centre for Nutrition, Department of Clinical Science, University of Bergen, Haukelandsbakken 15, 5009, Bergen, Norway; Corresponding author. Centre for Nutrition, Haukelandsbakken 15, 5021, Bergen, Norway.Centre for Nutrition, Department of Clinical Science, University of Bergen, Haukelandsbakken 15, 5009, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Jonas Lies Vei 65, 5021, Bergen, Norway; Mohn Nutrition Research Laboratory, University of Bergen, Haukelandsbakken 15, 5009, Bergen, NorwayInstitute of Marine Research, Nordnesgate 50, 5005, Bergen, NorwayCentre for Nutrition, Department of Clinical Medicine, University of Bergen, Haukelandsbakken 15, 5009, Bergen, Norway; Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Jonas Lies Vei 65, 5021, Bergen, Norway; Mohn Nutrition Research Laboratory, University of Bergen, Haukelandsbakken 15, 5009, Bergen, NorwayCentre for Nutrition, Department of Clinical Science, University of Bergen, Haukelandsbakken 15, 5009, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Jonas Lies Vei 65, 5021, Bergen, Norway; Mohn Nutrition Research Laboratory, University of Bergen, Haukelandsbakken 15, 5009, Bergen, NorwayPlasma concentrations of trimethylamine N-oxide (TMAO) have been linked to cardiovascular disease (CVD) risk and mortality. TMAO is formed through the bacterial conversion of trimethylamine which is obtained either directly from food, generated from dietary precursors (e.g. choline) or derived from endogenous trimethyllysine (TML) production. In a previous article, we reported an increased risk of acute myocardial infarction with increased total choline intake in patients with stable angina pectoris. Due to the close link between TMAO, TML, choline metabolism and possibly CVD, we investigated whether plasma TMAO and TML modified the effect of total choline intake on acute myocardial infarction (AMI) risk in a post-hoc analysis. We found plasma TMAO and TML do not modify the association between higher dietary choline intake and increased AMI risk. Additionally, this association is not mediated via TMAO.http://www.sciencedirect.com/science/article/pii/S2666149720300025Trimethylamine-N-oxide (TMAO)Trimethyllysine (TML)CholineMyocardial infarctionEffect modification |
| spellingShingle | Anthea Van Parys Vegard Lysne Jannike Øyen Jutta Dierkes Ottar Nygård No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris Human Nutrition & Metabolism Trimethylamine-N-oxide (TMAO) Trimethyllysine (TML) Choline Myocardial infarction Effect modification |
| title | No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris |
| title_full | No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris |
| title_fullStr | No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris |
| title_full_unstemmed | No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris |
| title_short | No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris |
| title_sort | no effect of plasma trimethylamine n oxide tmao and plasma trimethyllysine tml on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris |
| topic | Trimethylamine-N-oxide (TMAO) Trimethyllysine (TML) Choline Myocardial infarction Effect modification |
| url | http://www.sciencedirect.com/science/article/pii/S2666149720300025 |
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