Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from <i>Fibrodysplasia Ossificans Progressiva</i> Patients

Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from <i>Fibrodysplasia Ossificans Progressiva</i> Patients

<i>Fibrodysplasia Ossificans Progressiva</i> (FOP) is a rare genetic disease characterized by heterotopic ossification (HO). It is caused by mutations in the Activin receptor type 1 (<i>ACVR1</i>) gene, resulting in enhanced responsiveness to ligands, specifically to Activin-...

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Bibliographic Details
Main Authors: Ton Schoenmaker, Michal Mokry, Dimitra Micha, Coen Netelenbos, Nathalie Bravenboer, Marjolijn Gilijamse, E. Marelise W. Eekhoff, Teun J. de Vries
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
<i>fibrodysplasia ossificans progressiva</i>
Activin-A
periodontal ligament fibroblasts
RNA sequencing
heterotopic ossification
Online Access:https://www.mdpi.com/2227-9059/9/6/629

Internet

https://www.mdpi.com/2227-9059/9/6/629

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