P4.05 POLYCYSTIN DEFICIENCY RESULTS IN COMPLETE LOSS OF NO SYNTHESIS DURING SUSTAINED FLOW-MEDIATED DILATATION OF CONDUIT ARTERIES IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: POSSIBLE REVERSAL BY DOPAMINE

P4.05 POLYCYSTIN DEFICIENCY RESULTS IN COMPLETE LOSS OF NO SYNTHESIS DURING SUSTAINED FLOW-MEDIATED DILATATION OF CONDUIT ARTERIES IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: POSSIBLE REVERSAL BY DOPAMINE

Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is due to mutations in genes PKD1 and PKD2 encoding polycystin-1 and -2, which transduce flow variations into cellular signals in the renal epithelium but also in vascular endothelium. However, the impact of polycystin deficiency on th...

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Bibliographic Details
Main Authors: A. Lorthioir, R. Joannidès, I. Rémy-Jouet, C. Fréguin-Bouilland, M. Iacob, C. Monteil, D. Lucas, M.P. Audrezet, D. Guerrot, V. Richard, C. Thuillez, M. Godin, J. Bellien
Format: Article
Language:English
Published: BMC 2013-11-01
Series:Artery Research
Online Access:https://www.atlantis-press.com/article/125939021/view

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https://www.atlantis-press.com/article/125939021/view

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