Overexpression of Transcripts Coding for Renin-b but Not for Renin-a Reduce Oxidative Stress and Increase Cardiomyoblast Survival under Starvation Conditions

Overexpression of Transcripts Coding for Renin-b but Not for Renin-a Reduce Oxidative Stress and Increase Cardiomyoblast Survival under Starvation Conditions

A stimulated renin-angiotensin system is known to promote oxidative stress, apoptosis, necrosis and fibrosis. Renin transcripts (renin-b; renin-c) encoding a cytosolic renin isoform have been discovered that may in contrast to the commonly known secretory renin (renin-a) exert protective effects Her...

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Bibliographic Details
Main Authors: Heike Wanka, Philipp Lutze, Alexander Albers, Janine Golchert, Doreen Staar, Jörg Peters
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
cardiac H9c2 cells
cytosolic renin
secretory renin
ischemia-induced cell death
reactive oxygen species
mitochondrial membrane potential
Online Access:https://www.mdpi.com/2073-4409/10/5/1204

Internet

https://www.mdpi.com/2073-4409/10/5/1204

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