Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing
Human midbrain dopamine (DA) neurons are a heterogeneous group of cells that share a common neurotransmitter phenotype and are in close anatomical proximity but display different functions, sensitivity to degeneration, and axonal innervation targets. The A9 DA neuron subtype controls motor function...
Main Authors: | Alessandro Fiorenzano, Edoardo Sozzi, Malin Parmar, Petter Storm |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/10/6/1366 |
Similar Items
-
Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation
by: Fredrik Nilsson, et al.
Published: (2021-01-01) -
Silk scaffolding drives self-assembly of functional and mature human brain organoids
by: Edoardo Sozzi, et al.
Published: (2022-10-01) -
Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson’s Disease Drug Development
by: S. A. Antonov, et al.
Published: (2021-03-01) -
Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression?
by: Yongkang Wu, et al.
Published: (2024-01-01) -
α-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons
by: Xiaokang Jia, et al.
Published: (2024-04-01)