C. elegans XMAP215/ZYG-9 and TACC/TAC-1 act at multiple times during oocyte meiotic spindle assembly and promote both spindle pole coalescence and stability.

C. elegans XMAP215/ZYG-9 and TACC/TAC-1 act at multiple times during oocyte meiotic spindle assembly and promote both spindle pole coalescence and stability.

The conserved two-component XMAP215/TACC modulator of microtubule stability is required in multiple animal phyla for acentrosomal spindle assembly during oocyte meiotic cell division. In C. elegans, XMAP215/zyg-9 and TACC/tac-1 mutant oocytes exhibit multiple and indistinguishable oocyte spindle ass...

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Bibliographic Details
Main Authors: Austin M Harvey, Chien-Hui Chuang, Eisuke Sumiyoshi, Bruce Bowerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010363

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https://doi.org/10.1371/journal.pgen.1010363

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