Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions
Cultured brain slices from mice spontaneously upregulate senescence-associated genes over time and reproduce the transcriptional characteristics of aged brains; prions accelerate brain aging in brain slice cultures, animal models and human patients.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03496-5 |