Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells

Summary: Humanized mice, defined as mice with human immune systems, have become an emerging model to study human hematopoiesis, infectious disease, and cancer. Here, we describe the techniques to generate humanized NSGF6 mice using adult human CD34+ hematopoietic stem and progenitor cells (HSPCs). W...

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Bibliographic Details
Main Authors: Chun I. Yu, Rick Maser, Florentina Marches, Jacques Banchereau, Karolina Palucka
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166724003204