Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease

Abstract Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular membrane, and regulate cellular function. However, in the blood and brain of pati...

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Bibliographic Details
Main Authors: Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01176-4