Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

The human tau protein is implicated in a wide range of neurodegenerative “tauopathy” diseases, consisting of Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration, Pick’s disease, and FTLD-tau (frontotemporal dementia...

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Bibliographic Details
Main Authors: Ben Boyarko, Vivian Hook
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Neuroscience
Subjects:
tau isoforms
tau fragments
protease
mutations
neurotoxicity
tauopathies
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.702788/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.702788/full

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